Introduction: The Commission on Accreditation of Athletic Training Education mandates accredited athletic training programs have a minimum, three-year aggregate, first-attempt pass rate on the Board of Certification (BOC) examination of 70%. No studies have examined first-attempt BOC exam success for students enrolled in a professional master’s athletic training program (PMATP). Purpose: The purpose of this study was to identify factors associated with first-attempt success on the BOC examination for PMATP students. Methods: This cohort designed study used common application data from subjects’ university and PMATP applications to create prediction models to identify those factors that predict first-attempt success on the BOC exam. Results: A four-factor model was produced to predict first-attempt BOC exam success. Both models demonstrated a student with two, three or more predictors had an odds ratio of 16.0 or greater, a relative frequency of success of 1.45 or greater, and correctly predicted first-attempt success on the BOC exam over 92% of the time. Conclusions: It is possible to predict success on the BOC exam for students from a PMATP based on common application data. Recommendations: Although this project involved predicting success on the athletic training certification exam, the procedures and methods used could be adapted to any academic program.