Exposure to air pollution is associated with elevated cardiovascular risk. Evidence shows that omega-3 polyunsaturated fatty acids (omega-3 PUFA) may attenuate the adverse cardiovascular effects of exposure to fine particulate matter (PM2.5). However, it is unclear whether habitual dietary intake of omega-3 PUFA protects against the cardiovascular effects of short-term exposure to low-level ambient air pollution in healthy participants. In the present study, sixty-two adults with low or high dietary omega-3 PUFA intake were enrolled. Blood lipids, markers of vascular inflammation, coagulation and fibrinolysis, and heart rate variability (HRV) and repolarization were repeatedly assessed in 5 sessions separated by at least 7 days. This study was carried out in the Research Triangle area of North Carolina, USA between October 2016 and September 2019. Daily PM2.5 and maximum 8-h ozone (O3) concentrations were obtained from nearby air quality monitoring stations. Linear mixed-effects models were used to assess the associations between air pollutant concentrations and cardiovascular responses stratified by the omega-3 intake levels.
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Chen, Hao; Zhang, Siqi; Shen, Wan; Salazar, Claudia; Schneider, Alexandra; Wyatt, Lauren H.; Rappold, Ana G.; Diaz-Sanchez, David; Devlin, Robert B.; Samet, James M.; and Tong, Haiyan, "Omega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution" (2022). Public and Allied Health Faculty Publications. 21.
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