Individuals suffering from asthma typically have subnormal exercise tolerance and poor physical fitness. The purpose of this case series study was to examine the impact of a new aquatic exercise protocol on physiological variables in a group of asthmatics. Participants were medically diagnosed and managed asthmatics in a rural community. A total of 8 males and 12 females were accepted into the study with 7 males and 9 females completing the 12-week study. Physiological measures were taken pre- and posttreatment with paired t-tests used for analyses. Increases in VO2max (pre-treatment mean (M) = 31.244 SD = 9.772; post-treatment M = 33.431, SD = 10.387; partial ç²= .257, p < 0.038); lean body muscle mass (pre-treatment M = 119.606, SD = 28.210; post-treatment M = 122.012, SD = 30.475; partial ç²= .237, p < 0.047); and blood glucose (pre-treatment M = 83.937, SD = 7.584; post-treatment M = 89.812, SD = 7.799; partial ç²= .603, p < 0.000), were seen from pre- to posttreatment. The protocol was well tolerated and enjoyed by the participants suggesting it is useful in the asthmatic population. Our results predicted a need for larger sample size in future research ranging from 8 to 218 participants depending upon the dependent measure.