A supramolecular assay based on two fluorescent cucurbit[n]uril probes enables the recognition and quantification of nitrosamines, including cancer-associated nitrosamines, compounds that are difficult to recognize. The cross-reactive sensor leverages weak interactions and competition among the probe, metal, and guest, yielding high information density in the signal output (variance) and enabling the recognition of structurally similar guests.
Minami, Tsuyoshi; Esipenko, Nina A.; Zhang, Ben; Kozelkova, Maria E.; Isaacs, Lyle; Nishiyabu, Ryuhei; Kubo, Yuji; and Anzenbacher, Pavel Jr., "Supramolecular Sensor For Cancer-associated Nitrosamines" (2012). Chemistry Faculty Publications. 77.
Journal Of The American Chemical Society