Chemistry Faculty Publications
Ribostral: An RNA 3D Alignment Analyzer and Viewer Based on Basepair Isostericities
Document Type
Article
Abstract
RNA atomic resolution structures have revealed the existance of different families of basepair interactions, each of which with its own isosteric sub-families. Ribostral (Ribonucleic Structural Aligner) is a user-friendly framework for analyzing, evaluating and viewing RNA sequence alignments with at least one available atomic resolution structure. It is the first of its kind that makes direct and easy- to-understand superposition of the isostericity matrices of basepairs observed in the structure onto sequence alignments, easily indicating allowed and unallowed substitutions at each BP position. Potential mistakes in the alignments can then be corrected using other sequence editing software. Ribostral has been developed and tested under Windows XP, and is capable of running on any PC or MAC platform with MATLAB 7.1 (SP3) or higher installed version. A stand-alone version is also available for the PC platform.
Copyright Statement
Publisher PDF
Publisher's Statement
Availability via databases maintained by the United States National Library of Medicine.
Repository Citation
Mokdad, Ali and Leontis, Neocles B., "Ribostral: An RNA 3D Alignment Analyzer and Viewer Based on Basepair Isostericities" (2006). Chemistry Faculty Publications. 46.
https://scholarworks.bgsu.edu/chem_pub/46
Publication Date
9-1-2006
Publication Title
Bioinformatics
Start Page No.
2168
End Page No.
2170