Chemistry Faculty Publications
Document Type
Article
Abstract
A supramolecular sensor array composed of two fluorescent cucurbit[n]uril-type receptors (probe 1 and probe 2) displaying complementary selectivities was tested for its ability to detect and quantify drug-related amines. The fluorimetric titration of the individual probes showed highly variable and cross-reactive analyte-dependent changes in fluorescence. An excellent ability to recognize a variety of analytes was demonstrated in qualitative as well as quantitative assays. Importantly, a successful quantitative analysis of several analytes of interest was achieved in mixtures and in human urine. The throughput and sensitivity surpass those of the current state-of-the-art methods that usually require analyte solid-phase extraction (SPE). These results open up the opportunity for new applications of cucurbit[n]uril-type receptors in sensing and pave the way for the development of simple high-throughput assays for various drugs in the near future.
Copyright Statement
Publisher PDF
Repository Citation
Minami, Tsuyoshi; Esipenko, Nina A.; Akdeniz, Ali; Zhang, Ben; Isaacs, Lyle; and Anzenbacher, Pavel Jr., "Multianalyte Sensing Of Addictive Over-the-counter (otc) Drugs" (2013). Chemistry Faculty Publications. 125.
https://scholarworks.bgsu.edu/chem_pub/125
Publication Date
10-2013
Publication Title
Journal Of The American Chemical Society
DOI
https://doi.org/10.1021/ja407722a
Start Page No.
15238
End Page No.
15243