Biological Sciences Faculty Publications
Morphological fractal analysis of shape in cancer cells treated with combinations of microtubule-polymerizing and -depolymerizing agents
Document Type
Article
Abstract
The current prognostic parameters, including tumor volume, biochemistry, or immunohistochemistry, are not sufficient to reflect the properties of cancer cells that distinguish them from normal cells. Our focus is to evaluate the effects of a combination of microtubule-polymerizing Taxol (R) and -depolymerizing colchicine on IAR20 PC1 liver cells by measuring the surface fractal dimension as a descriptor of two-dimensional vascular geometrical complexity. The fractal dimension offers a rapid means of assessing cell shape. Furthermore, we show correlations of fractal dimensions of cell contours with the latent factors from our previously employed cell shape analysis.
Repository Citation
Uppal, S. O.; Voronine, D. V.; Wendt, E.; and Heckman, Carol A., "Morphological fractal analysis of shape in cancer cells treated with combinations of microtubule-polymerizing and -depolymerizing agents" (2010). Biological Sciences Faculty Publications. 58.
https://scholarworks.bgsu.edu/bio_sci_pub/58
Publication Date
8-2010
Publication Title
Microscopy and Microanalysis
DOI
https://doi.org/10.1017/S1431927610000358
Start Page No.
472
End Page No.
477