Chemistry Faculty Publications

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Mechanistic studies of biological electron-transfer (ET) reactions have involved the use of surface-derivatized proteins, protein−protein complexes, and polypeptide-bridged donor−acceptor compounds. These latter studies seek to use well-defined model systems to better define the role of the intervening protein matrix in mediating biological electron transfers. However, whereas many in vivo ET reactions occur across a noncovalent protein−protein interface, the primary role of the peptide spacers found in current model systems is to provide a covalent link between the donor and acceptor sites. As such, these systems are poorly suited to probe the mechanisms of ET reactions occurring across a peptide−peptide interface.

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Journal Of The American Chemical Society

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Chemistry Commons