Metal coordination is used to alter the oligomerization state of a designed peptide structure. The 30-residue polypeptide AQ-Pal21 4Pal21 contains two metal-binding 4-pyridylalanine (Pal) residues on its solvent-exposed surface and exists as a very stable two-stranded a-helical coiled-coil. Upon the addition of Pt(en)(NO3)(2), a significant conformational change to a metal-bridged, four-helix bundle is seen.
Tsurkan, Mikhail V. and Ogawa, Michael Y., "Metal-mediated Peptide Assembly: Use Of Metal Coordination To Change The Oligornerization State Of An Alpha-helical Coiled-coil" (2007). Chemistry Faculty Publications. 129.
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