Biological Sciences Faculty Publications

Title

Morphological fractal analysis of shape in cancer cells treated with combinations of microtubule-polymerizing and -depolymerizing agents

Document Type

Article

Abstract

The current prognostic parameters, including tumor volume, biochemistry, or immunohistochemistry, are not sufficient to reflect the properties of cancer cells that distinguish them from normal cells. Our focus is to evaluate the effects of a combination of microtubule-polymerizing Taxol (R) and -depolymerizing colchicine on IAR20 PC1 liver cells by measuring the surface fractal dimension as a descriptor of two-dimensional vascular geometrical complexity. The fractal dimension offers a rapid means of assessing cell shape. Furthermore, we show correlations of fractal dimensions of cell contours with the latent factors from our previously employed cell shape analysis.

Publication Date

8-2010

Publication Title

Microscopy and Microanalysis

Volume

16

Issue

4

Start Page No.

472

End Page No.

477

ISSN

1431-9276

DOI

10.1017/S1431927610000358

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